The Role of Amyloid PET in Diagnosing Possible Transmissible Cerebral Amyloid Angiopathy in Young Adults with a History of Neurosurgery: A Case Series

<b><i>Background:</i></b> Cerebral amyloid angiopathy (CAA) is a common cause of cerebrovascular disease in the elderly. There accumulating evidence suggestive transmissibility β-amyloid resulting pathology at younger age. According to Boston criteria, defining CAA patients <55 years requires histological which may hamper diagnosis. We explored role PET diagnosis possible transmissible young adults. <b><i>Cases:</i></b> report 4 adults (<55 years) presenting with clinical and neuroimaging features but without genetic hereditary explaining onset. A factor all cases was medical history neurosurgery during childhood. All underwent support an amyloid-related result positive 4. <b><i>Conclusion:</i></b> Combining presentation imaging findings cases, we postulate as Further epidemiological studies are required gain more insight prevalence this novel entity. Amyloid be useful, non-invasive tool these analyses especially since pathological will lacking most studies.